The Cook Labs records, which date from 1939-2002, document the activities of audio engineer Emory Cook and his label Cook Labs. The contents include business records, materials relating to recording artists, photographs, and production materials, as well as phonograph records, master recordings and unpublished recordings produced by or associated with the Cook Labs label. The collection also contains two interviews conducted with Emory Cook in 1990: one by Jeff Place and one by Anthony Seeger and Nicholas Spitzer. There are several physical objects relating to Cook Labs including a bag of powdered vinyl, a binaural playing arm, and a condenser microphone.

Correspondence with artists kept by Russell Lynes in his capacity as managing editor of Harper's Magazine, measures one linear foot and dates from 1946 to 1965. The files consist primarily of correspondence with young artists and illustrators wishing to submit material to the magazine. Biographical notes from the magazine's "Personal and Otherwise" column about the artists whose material was accepted, clippings, scattered original artwork, and printed reproductions of artwork, are also included.

The records of the Perls Galleries measure 79.6 linear feet and date from 1937 to 1997. Founded by Klaus Perls in 1937 and operating until 1997, the gallery dealt primarily in modern French art and the artwork of Alexander Calder. Found within the records are extensive correspondence (circa 44 linear feet) with artists, dealers, galleries, museums, and collectors; photographs and negatives of inventory and other artwork; exhibition files, scattered financial records; and exhibition catalogs and clippings.

The Charlene Hodges Byrd collection measures 43 linear feet, and dates from circa 1750-2009, with the bulk of the material dating from 1880-1960. The collection documents the personal life and professional career of Charlene Hodges Byrd, an African American teacher from Washington, D.C., along with material for several related families from Pennsylvania, Maryland, and Washington, D.C. Family members prominently represented include Sarah A. Shimm, teacher and essayist under the name Faith Lichen; her daughters Erminie F. Shimm and Grace E. Shimm Cummings, both teachers; and Byrd's mother, Joyce Ethel Cummings Hodges, also a teacher. Correspondence and writings chiefly discuss family life, religion, race, education, and the relationship with Frederick Douglass and his family. The collection is arranged in 10 series: Biographical Material, Correspondence, Writings, Subject Files, Financial and Legal Records, Printed Material, Volumes, Memorabilia, Textiles, and Photographs.

The Lee Nordness business records and papers measure 117.5 linear feet and date from circa 1931 to 1992 with the bulk of materials dating from 1954 to 1984. The records document seven New York City art-related companies with which Nordness was involved: Talent Discovery Company, The Little Studio, Ltd., American Art Expositions, Inc., Nordness Gallery, Inc., Lee Nordness Galleries Art Advisory Section, Inc., Lee Nordness Galleries Exhibition Section, Inc., and Forms & Objects, Inc. Records include correspondence, artist's files, business and legal records, inventories, financial and sales records, printed materials, scrapbooks, and photographic materials. Also found is a small group of personal papers.

The papers of art historian, educator, editor, and museum director Robert John Goldwater measure 5.4 linear feet and date from 1902-1974. Found are correspondence, subject files, teaching records, writings, and printed material. Also included are the papers, primarily correspondence, of Goldwater's father, S. S. Goldwater, M. D., a nationally recognized expert in the fields of public health, hospital administration, and hospital design and construction.

The Computer Oral History Collection (1969-1973, 1977), was a cooperative project of the American Federation of Information Processing Societies (AFIPS) and the Smithsonian Institution. This project began in 1967 with the main objective to collect, document, house, and make available for research source material surrounding the development of the computer.

Papers documenting the farming and family life of the Robinson family of Prince George's County and after 1975, Charles County, Maryland. Papers documenting the farming and family of the Via family of Greene County, Virginia, Washington, D.C., Prince George's and Calvert Counties, Maryland, by 1949.

The Charles Henry Hart autograph collection dates from 1731-1917 and measures 1.71 linear feet comprised of 232 letters, portrait prints, and other documents signed by American artists. There is a .01 linear foot (6 items) unprocessed addition to this collection donated in 2021 that includes a letter from Winslow Homer to Mr. Clarke, November 28, 1892; typed and annotated lists of autographs of artists in the collections of Charles Henry Hart; handwritten note about English painter and engraver, John Keyse Sherwin, undated; handwritten note regarding Gennearino Persico, miniature artist, July 18, 1826.

The papers of folk art collector and museum curator Herbert Waide Hemphill date from 1776-1998, bulk 1876-1998, and measure 26.7 linear feet. Found within the papers are biographical materials, personal business records, files documenting his collecting, writings, art work, minutes of meetings, a scrapbook, printed material including exhibition and auction announcements and catalogs, and miscellaneous artifacts. The collection also contains numerous photographs of Hemphill, family members, his residences, friends and colleagues, exhibitions, travel, and art work. Sound and video recordings include interviews of Hemphill.