George Hubbard Pepper specialized in the study of cultures of the American Southwest and Ecuador. Tribes which he studied are Acoma, Aztec, Blackfeet, Cochiti, Hopi, Isleta, Jemez, Laguna, Nambe, Navajo, Picuris, Pojuaque, Puye, San Carlos Apache, San Felipe, San Ildefonso, San Juan, Sandia, Santa Ana, Santa Clara, Taos, Tarascan, Tesuque, Ute, Zia, and Zuni. Photographs in the collection are of an excavation in Tottenville, New York, 1895; Pueblo Bonito in Chaco Cañon, New Mexico: Hyde Expedition, 1896-1900; and expeditions to the occupied Pueblos of the Southwest, 1904; Mexico, 1904, 1906; Guatemala; and Ecuador, 1907. There are also photos which complement a study Pepper did of the technique of Navajo weaving, and miscellaneous scenic and personal photos.
64 aerial photographs of Rio Grande Pueblos made circa 1967 from 60,000 feet by a U2 aircraft.